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• Women Deliver Conference: Register here for the Pre-eclampsia 2013: A Global Symposium
• PRE-EMPT Newsletter March 2013
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The miniPIERS model is being developed to aid in case identification/diagnosis and risk stratification in women with hypertensive disorders of pregnancy and will include women across the full spectrum of the HDP (pre-eclampsia, gestational hypertension and chronic hypertension) to improve generalisability. We expect that the miniPIERS model will facilitate and accelerate appropriate triage and transport to centers where women can then receive effective and evidence-based treatment to avert the adverse maternal and perinatal consequences of pre-eclampsia. Modelling will require data acquisition from 2,500 – 3,000 women admitted to miniPIERS sites in Bra­zil (São Paulo), China (Shanghai), Fiji (Suva), Mali (Bamako), Pakistan (Karachi & Hyderabad), South Africa (Cape Town), and Uganda (Kampala). 

The CAP (Calcium and Pre-eclampsia) trial is a double-blind placebo-controlled randomized controlled trial (RCT) of pre-pregnancy and early pregnancy (<20 weeks) calcium supple­mentation in women with low calcium intake and at high risk for pre-eclampsia in their next pregnancy. The goal of this South African and Zimbabwean RCT is to determine whether or not calcium supple­mentation before, and in the first half of, pregnancy prevents both the diagnosis and consequences of pre-eclampsia. If the CAP intervention is effective, this would lay the groundwork for studies of food fortification to ad­dress calcium deficiency at a community level. This collaboration includes the World Health Organization HRP and Instituto de Efectividad Clínica y Sanitaria (IECS), Buenos Aires. 

CLIP(Community Level Interventions for Pre-Eclampsia) Trial includes CLIP Feasibility Study, CLIP Pilot and the Gynuity Health Projects’ Oral Antihypertensive Trial. The ultimate aim of the CLIP trial initiative is to test the impact of a community-level package of care to reduce adverse maternal and perinatal outcomes related to pre-eclampsia. The CLIP Feasibility study is examining any potential barriers that may impact the successful conduction of the CLIP Pilot trial. A maternal mortality and severe morbidity audit in CLIP Feasbility and research on therapeutics in the CLIP Feasibility and CLIP Pilot are also a part of this objective. The Gynuity Health Projects’ Oral Anti­hypertensive Trial will provide important informa­tion to guide antihypertensive agent selection for the definitive CLIP trial. 

The Global Pregnancy CoLaboratory has short-term goals to bring together cohorts with data and biological samples from around the world to study the pregnancy disorder, pre-eclampsia. Thus, a longer-term goal of the effort is to introduce such data and collections into LMICs and to extend the target of the research across the breadth of pregnancy com­plications.

The primary goal of Knowledge Translation  is the develop­ment of an updated set of WHO recommendations for the prevention and management of pre-eclamp­sia and eclampsia. The development, dissemina­tion, and implementation of evidence based and culturally appropriate knowledge translation tools for both well- and low resourced settings is critical in effecting a reduction in the burden of life-ending, life-threatening, and life-altering maternal and peri­natal complications of pre-eclampsia/eclampsia.